Chromatography Standards
Cayman Chemical Temozolomide, Purity: ≥98%, CAS: 85622-93-1, 25 mg
A prodrug form of MTIC; selectively cytotoxic to MGMT-deficient U87 and D54 cells over MGMT-expressing T98G and U3054MG cells (IC50s = 51, 12, 660, and 370 µM, respectively); increases survival in a Br23c glioblastoma orthotopic mouse xenograft model at 15 mg/kg; decreases tumor volume and increases the number of tumor-infiltrating CD4+ and CD8+ T cells in a GL261 murine glioma model in combination with anti-CD47
Sigma Aldrich Fine Chemicals Biosciences Pioglitazone hydrochloride United States Pharmacopeia (USP) Reference Standard | 112529-15-4 | MFCD04975446 | 100MG
Pioglitazone hydrochloride United States Pharmacopeia (USP) Reference Standard | Mol Wt: 392.9 | 112529-15-4 | MFCD04975446 | 100MG
Medchemexpress LLC Berberine hemisulfate | 316-41-6 | 384.40 | 1 G
Berberine hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian. This compound demonstrates anti-inflammatory, antibiobic, antitumor, cardiovascular protective, and neuroprotective activities, and is intended for research use only.
- Exhibits antimicrobial activity by inhibiting cell division protein FtsZ or through DNA/RNA binding.
- Shows anti-inflammatory activity by inhibiting TNF-α and its downstream pathways AP-1 and NF-kB.
- Provides neuroprotective efficacy by inhibiting reactive oxygen species (ROS) production and caspase activation.
- Attenuates metabolic diseases by regulating lipid composition and inhibiting insulin resistance.
Medchemexpress LLC Amoxicillin (trihydrate) mixture with potassium clavulanate (4:1) | 25 MG
Amoxicillin (trihydrate) mixture with potassium clavulanate (4:1) is an antibiotic characterized by good oral absorption and broad-spectrum antimicrobial activity. It functions by inhibiting the biosynthesis of polypeptides in the cell wall, thereby hindering cell growth.
- Good oral absorption
- Broad-spectrum antimicrobial activity
- Inhibits biosynthesis of polypeptides in the cell wall
- Inhibits cell growth
- For research use only
Medchemexpress LLC Neostigmine methyl sulfate | 51-60-5 | 98.9% | 100 MG
Neostigmine methyl sulfate (Standard) serves as an analytical standard, designed for research and analytical applications. This reference standard assay is widely utilized in qualitative, quantitative, and methodological research experiments, including techniques such as HPLC, GC, and MS.
- Intended for research and analytical applications.
- Functions as a reference standard supplied assay.
- Used in qualitative, quantitative, and methodological research.
- Suitable for techniques including HPLC, GC, and MS.
Cayman Chemical 5-trans Latanoprost (free acid), Purity: ≥95%, CAS: 903549-49-5, 1 mg
An isomer of latanoprost (free acid) wherein the double bond between carbons 5 and 6 has been changed from cis (Z) to trans (E); intended primarily as an analytical standard
Medchemexpress LLC Mifepristone | 84371-65-3 | 99.9% | 429.59 | 1 ML
Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay. It was discovered as the first competitive progesterone antagonist, stimulating a search for more potent and selective antiprogestins.
- Progesterone receptor and glucocorticoid receptor antagonist
- Inhibits cell growth
- Potentiates doxorubicin-induced cytotoxicity in K562/R7 cells
- Reduces severity of EtOH withdrawal in vivo
Medchemexpress LLC Promazine hydrochloride | 53-60-1 | 99.9% | 1 ML
Promazine hydrochloride is an antipsychotic and a dopamine receptor D2 antagonist that inhibits dopaminergic neurotransmission. It is supplied as a solid, white to off-white powder.
- Antipsychotic and dopamine receptor D2 antagonist
- Inhibits dopaminergic neurotransmission
- Shows KDs of 25, 190, and 8400 nM at human norepinephrine, serotonin, and dopamine transporters
- Molecular weight: 320.88
- Chemical formula: C17H21ClN2S
- Soluble in water and DMSO at 100 mg/mL
Apexbio Technology LLC Fostamatinib (R788) 901119-35-5 100mg
Fostamatinib (R788 CAS 901119-35-5) is an orally available small-molecule inhibitor targeting spleen tyrosine kinase (Syk) with an IC50 of approximately 41 nM As a prodrug fostamatinib is rapidly converted to its active metabolite R406 an ATP-competitive inhibitor of Syk (Ki 30 nM) R406 additionally inhibits related kinases such as Flt3 Lyn (IC50 63 nM) and Lck (IC50 37 nM) thereby modulating BCR- and Fc receptor-mediated signaling pathways Preclinical studies demonstrate activity of fostamatinib in various autoimmune and inflammatory models including SLE-related nephritis and dermatitis in MRL/lpr mice highlighting its utility as a research tool in autoimmune disease investigation
Apexbio Technology LLC Eltrombopag Olamine 496775-62-3 50mg
Eltrombopag Olamine is an orally bioavailable thrombopoietin receptor (c-mpl) agonist that directly stimulates platelet production through activation of the JAK2/STAT signaling pathway In cellular assays using murine BAF3 cells expressing human thrombopoietin receptor (hTpoR) eltrombopag induced STAT-dependent signaling responses with an EC50 value of approximately 0 27 M This compound promotes differentiation of human CD34 progenitor cells into megakaryocytes capable of platelet production Eltrombopag is commonly applied in hematological research particularly in studies involving thrombocytopenia and thrombopoiesis-related mechanisms
Sigma Aldrich Fine Chemicals Biosciences Dibenzosuberone European Pharmacopoeia (EP) Reference Standard | 1210-35-1 | MFCD00003587 |
Dibenzosuberone European Pharmacopoeia (EP) Reference Standard | Mol Wt: 208.26 | 1210-35-1 | MFCD00003587 |
Medchemexpress LLC Neriifolin | 466-07-9 | 1 MG
Neriifolin is a CNS-penetrating cardiac glycoside that functions as an inhibitor of Na+, K+-ATPase. It targets beclin 1, inhibiting the formation of LC3-associated phagosomes and ameliorating the development of experimental autoimmune encephalomyelitis (EAE). This compound induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells, making it suitable for laboratory research applications.
- CNS-penetrating cardiac glycoside
- Inhibitor of Na+, K+-ATPase
- Targets beclin 1
- Inhibits LC3-associated phagosome formation
- Ameliorates experimental autoimmune encephalomyelitis (EAE) development
- Induces cell cycle arrest and apoptosis in HepG2 cells
- Purity: 99.70%
- Appearance: Solid
- Color: White to yellow
- Molecular weight: 534.68
- Soluble in DMSO (100 mg/mL)
Sigma Aldrich Fine Chemicals Biosciences Sodium acetate trihydrate | 6131-90-4 | MFCD00071557 | 1 g
Sodium acetate trihydrate | Mol Wt: 136.08 | 6131-90-4 | MFCD00071557 | 1 g
Medchemexpress LLC Benzarone | 1477-19-6 | 99.7% | 266.29 | 500 MG
Benzarone is an oral inhibitor of human urate transporter 1 (hURAT1) with an IC50 value of 2.8 μM, and it also functions as an uncoupler of oxidative phosphorylation. This compound has the potential to cause liver damage and can promote cell apoptosis and necrosis. It is utilized to reduce serum uric acid levels and for research related to vascular diseases.
- Oral inhibitor of human urate transporter 1 (hURAT1).
- Functions as an uncoupler of oxidative phosphorylation.
- Used to lower serum uric acid levels.
- Useful for research in vascular diseases.
- May cause liver damage and promote cell apoptosis and necrosis.
Medchemexpress LLC Larotrectinib | 1223403-58-4 | 99.9% | 10 MG
Larotrectinib is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors. It demonstrates low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C) and exhibits 1,000-fold or greater selectivity relative to other kinases. This product is for research use only.
- Targets TrkA, TrkB, and TrkC
- Exhibits antiproliferative activity against various cell lines
- Demonstrates dose-dependent inhibition of cell proliferation
- Has low brain penetration in animal studies
- Well tolerated in GLP toxicology studies
- Reduces tyrosine phosphorylation of TRKA and downstream signal transduction in tumors
- Shows dose-dependent tumor inhibition in athymic nude mice
- Reduces leukemic infiltration in bone marrow and spleen in mice